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Differential influences of peroxisome proliferator-activated receptors[gamma] and -[alpha] on food intake and energy homeostasis - Obesity Studies
Chronic treatment with compounds activating peroxisome proliferator-activated receptor (PPAR)[gamma] and -[alpha] influences body energy stores, but the underlying mechanisms are only partially know...(Continue Reading) Peroxisome proliferator-activated receptor -[alpha] activation prevents diabetes in OLETF rats: comparison with PPAR-[gamma] activation - PPAR - Pathophysiology
Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes in obese subjects. We examined the potential preventive ......(Continue Reading)TNF[alpha] reduces the expression of PPAR[gamma] via the production of ceramide and the activation of atypical PKC - Adipocyte Biology
Although TNF[alpha] decreases the expression of PPAR[gamma], its mechanism has not been understood. We evaluated the effect of ceramide, the second messenger ......(Continue Reading)Preclinical characterization of a dual PPAR[alpha]/[gamma] agonist-MK-767 - Clinical Therapeutics/New Technology—Pharmacologic Treatment Of Diabetes
Patients with type 2 diabetes often have dyslipidemia and have an increased incidence of atherosclerotic disease events. No single currently available ......(Continue Reading)LY510929: a highly potent, non-TZD PPAR [alpha], [gamma] dual agonist for the treatment of type 2 diabetes and associated dyslipidemia - Clinical Therapeutics/New
LY510929, a non-thiazolidinedione, is a unique, balanced dual agonist for human PPAR [alpha] and PPAR [gamma]. In vitro LY510929 binds selectively to ......(Continue Reading)
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