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Regulation of [alpha]-cell function by the [beta]-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis
The "switch-off" hypothesis to explain [beta]-cell regulation of [alpha]-cell function during hypoglycemia has not been assessed previously ......(Continue Reading) Regulation of [alpha]-cell function by the [beta]-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis
The glucagon response is the first line of defense against hypoglycemia and is lost in insulin-dependent diabetes. The [beta]-cell "switch-off" ......(Continue Reading)Nuclear factor [kappa]B protects pancreatic [beta]-cells from tumor necrosis factor-[alpha]—mediated apoptosis - Islet Studies
Recent studies incriminating tumor necrosis factor (TNF)-[alpha] as the final effector in pancreatic [beta]-cell death in type 1 diabetes underscore the potential role of TNF-[alpha]-dependent NF-[k...(Continue Reading)Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase C-[alpha] and-[beta]
Diabetes confers an increased propensity to atherosclerosis. Inflammation is pivotal in atherogenesis, and diabetes is a proinflammatory state. Interleukin ......(Continue Reading)[beta]-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1[alpha] in mice: diabetes model with [beta]-cell dysfunction
We studied islet function in mice with [beta]-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor (HNF)-1[alpha]. At age 2-3 months, anesthetized transgenic and wild-...(Continue Reading)
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