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Endurance training increases protein expression of AMP-activated protein kinase subunits [[alpha].sub.1] and [[beta].sub.2], and decreases [[gamma].sub.3]
Endurance training is known to induce changes in expression of numerous proteins in skeletal muscle, allowing for a more oxidative mode of energy metabolism ......(Continue Reading) Nuclear factor [kappa]B protects pancreatic [beta]-cells from tumor necrosis factor-[alpha]—mediated apoptosis - Islet Studies
Recent studies incriminating tumor necrosis factor (TNF)-[alpha] as the final effector in pancreatic [beta]-cell death in type 1 diabetes underscore the potential role of TNF-[alpha]-dependent NF-[k...(Continue Reading)Role of peroxisome proliferator-activated receptor-[gamma] in the glucose-sensing apparatus of liver and [beta]-cells
Type 2 diabetes develops in the context of both insulin resistance and [beta]-cell failure. Thiazolidinediones are a class of antidiabetic agents that ......(Continue Reading)Glucose inhibition of glucagon secretion from rat [alpha]-cells is mediated by GABA released from neighboring [beta]-cells
[gamma]-Aminobutyric acid (GABA) has been proposed to function as a paracrine signaling molecule in islets of Langerhans. We have shown that rat [beta]-cells ......(Continue Reading)Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-[gamma], transforming growth factor-[beta]1,
Thiazolidinediones, such as pioglitazone, seem to exert direct antiatherosclerotic and antirestenotic effects on type 2 diabetes, in part due to an induction ......(Continue Reading)
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