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Association testing of variants in the hepatocyte nuclear factor 4[alpha] gene with risk of type 2 diabetes in 7,883 people
Two recent publications reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4[alpha] (HNF4[alpha]) (the MODY1 ......(Continue Reading) Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by [alpha]-cells of islet of Langerhans
In islets of Langerhans, L-glutamate is stored in glucagon-containing secretory granules of [alpha]-cells and cosecreted with glucagon under low-glucose ......(Continue Reading)A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4[alpha] gene on chromosome 20q is associated with type 2 diabetes
Variants in hepatocyte nuclear factor-4[alpha] (HNF4[alpha]), a transcription factor that influences the expression of glucose metabolic genes, have been correlated with maturity-onset diabetes of t...(Continue Reading)Protein kinase B-[alpha] inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
Starvation and diabetes increase pyruvate dehydrogenase kinase-4 (PDK4) expression, which conserves gluconeogenic substrates by inactivating the pyruvate ......(Continue Reading)Genetic variation near the hepatocyte nuclear factor-4[alpha] gene predicts susceptibility to type 2 diabetes
The Finland-United States Investigation Of NIDDM Genetics (FUSION) study aims to identify genetic variants that predispose to type 2 diabetes by studying ......(Continue Reading)
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